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Article: Favoring inhibitory synaptic drive mediated by GABAA receptors in the basolateral nucleus of the amygdala efficiently reduces pain symptoms in neuropathic mice.

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Zeitler A; Kamoun N; Goyon S; Wahis J; Charlet A; Poisbeau P; Darbon P
Eur. J. Neurosci., 2016


Table 1. Changes in miniature GABAAR-mediated IPSCs after application of EFX (60 μm) in the absence (top three lines) and presence (bottom three lines) of the 5α-reductase inhibitor finasteride (FIN, 10 μm)
ConditionsFreq. (Hz)Area (pA.ms)Amp. (-pA)Decay (ms)N
Control3.2 ± 0.5222.6 ± 20.613.6 ± 1.217.3 ± 1.317
EFX (60 μm) 5.4 ± 0.8 *** 334.9 ± 26.7 ** 18.3 ± 1.3 ** 21.0 ± 1.2 * 17
Washout3.9 ± 0.5 299.0 ± 22.6 * 15.1 ± 1.3 21.3 ± 2.0 * 13
Control in FIN2.8 ± 0.8192.3 ± 27.815.3 ± 2.917.8 ± 1.28
EFX (60 μm) in FIN 5.6 ± 1.0 * 209.9 ± 33.514.5 ± 2.717.6 ± 1.28
Washout in FIN2.5 ± 0.6206.8 ± 31.816.6 ± 2.317.7 ± 1.67

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Inferred neuron-electrophysiology data values

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